Job Description

Eurofins PSS seeks a PhD-level scientist to lead development and scale-up of E. coli fermentation processes for a proprietary DNA manufacturing platform. The role spans bench to pilot scale, encompassing process design, optimization, documentation, and technology transfer to external manufacturing partners.

Responsibilities

• Design, execute, and optimize E. coli fermentation processes from shake flask through pilot-scale bioreactors
• Drive yield and consistency improvements through systematic optimization of strain, media, feed strategy, and process parameters
• Define process design space and identify critical process parameters using design of experiments methodology
• Establish scale-independent criteria to ensure bench-scale performance is reproducible at larger scales
• Author technical documentation and generate packages supporting GLP studies and technology transfer to external partners

Requirements

• PhD in chemical engineering, biochemical engineering, biotechnology, microbiology, or related field
• 1+ years hands-on bacterial fermentation process development in instrumented bioreactors
• Experience independently designing and executing fermentation experiments at ≥2 L working volume
• Demonstrated proficiency with design of experiments and statistical analysis methods
• Strong technical writing skills evidenced by development reports, protocols, or publications
• Hands-on experience with modern bioreactor control platforms (Sartorius, Eppendorf/DASGIP, or Ambr)
• Experience with high-cell-density fed-batch E. coli fermentation and scaling constraints

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